MovDisordV3, Main, Exploration, bibRecord, 003C44

Neuronal activity in the globus pallidus of multiple system atrophy patients

Identifieur interne : 003C44 ( Main/Exploration ); précédent : 003C43; suivant : 003C45

Neuronal activity in the globus pallidus of multiple system atrophy patients

Auteurs : Luiz C. M. Pereira [Canada] ; Vanessa N. Palter [Canada] ; Anthony E. Lang [Canada] ; William D. Hutchison [Canada] ; Andres M. Lozano [Canada] ; Jonathan O. Dostrovsky [Canada]

Source :

Movement Disorders [ 0885-3185 ] ; 2004-12.

RBID : ISTEX:F4C316FFBEBBC54817DB712BC57CEC1CBDCC3AA0

Descripteurs français

Pascal (Inist)
- Atrophie multisystématisée, Homme, Système nerveux pathologie.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Aged, Anticonvulsants (therapeutic use), Antiparkinson Agents (therapeutic use), BG, Female, Globus Pallidus (physiopathology), Globus Pallidus (surgery), Human, Humans, Levodopa (therapeutic use), MSA, Male, Microelectrodes, Middle Aged, Multiple System Atrophy (physiopathology), Multiple System Atrophy (surgery), Multiple system atrophy, Nervous system diseases, Neurosurgical Procedures (instrumentation), PD, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson Disease (surgery), globus pallidus, recordings.
MESH :
- chemical , therapeutic use : Anticonvulsants, Antiparkinson Agents, Levodopa.
- drug therapy : Parkinson Disease.
- instrumentation : Neurosurgical Procedures.
- physiopathology : Globus Pallidus, Multiple System Atrophy, Parkinson Disease.
- surgery : Globus Pallidus, Multiple System Atrophy, Parkinson Disease.
- Adult, Aged, Female, Humans, Male, Microelectrodes, Middle Aged.

Abstract

The pathophysiological changes in neural activity that characterize multiple system atrophy (MSA) are largely unknown. We recorded the activity of pallidal neurons in 3 patients with clinical and radiological features of MSA who underwent unilateral microelectrode‐guided pallidotomy for disabling parkinsonism. Findings in these patients were compared with 4 control patients with a clinical diagnosis of Parkinson's disease (PD). The position, firing rates, and firing patterns of single neurons in the pallidal complex were analyzed in both MSA and PD patients. The mean spontaneous firing rate of neurons in the internal segment of the globus pallidus internus (GPii) was significantly lower in MSA than in PD patients. There were no significant differences between MSA and PD patients, however, in firing rates of neurons in the external globus pallidus (GPe) or in the external segment of GPi (GPie). In addition, no significant differences in firing pattern were found between MSA and PD patients. In conclusion, this study has shown that firing rates of neurons in GPii but not in GPie and GPe are different in MSA patients compared with that in PD patients, a finding that may reflect the poor clinical results of pallidotomy reported in patients with MSA. © 2004 Movement Disorder Society

Url:

https://api.istex.fr/document/F4C316FFBEBBC54817DB712BC57CEC1CBDCC3AA0/fulltext/pdf

DOI: 10.1002/mds.20236

Affiliations:

Le document en format XML

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<term>Aged</term>
<term>Anticonvulsants (therapeutic use)</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>BG</term>
<term>Female</term>
<term>Globus Pallidus (physiopathology)</term>
<term>Globus Pallidus (surgery)</term>
<term>Human</term>
<term>Humans</term>
<term>Levodopa (therapeutic use)</term>
<term>MSA</term>
<term>Male</term>
<term>Microelectrodes</term>
<term>Middle Aged</term>
<term>Multiple System Atrophy (physiopathology)</term>
<term>Multiple System Atrophy (surgery)</term>
<term>Multiple system atrophy</term>
<term>Nervous system diseases</term>
<term>Neurosurgical Procedures (instrumentation)</term>
<term>PD</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (surgery)</term>
<term>globus pallidus</term>
<term>recordings</term>
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<term>Antiparkinson Agents</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Neurosurgical Procedures</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Globus Pallidus</term>
<term>Multiple System Atrophy</term>
<term>Parkinson Disease</term>
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<term>Multiple System Atrophy</term>
<term>Parkinson Disease</term>
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<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Microelectrodes</term>
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<front><div type="abstract" xml:lang="en">The pathophysiological changes in neural activity that characterize multiple system atrophy (MSA) are largely unknown. We recorded the activity of pallidal neurons in 3 patients with clinical and radiological features of MSA who underwent unilateral microelectrode‐guided pallidotomy for disabling parkinsonism. Findings in these patients were compared with 4 control patients with a clinical diagnosis of Parkinson's disease (PD). The position, firing rates, and firing patterns of single neurons in the pallidal complex were analyzed in both MSA and PD patients. The mean spontaneous firing rate of neurons in the internal segment of the globus pallidus internus (GPii) was significantly lower in MSA than in PD patients. There were no significant differences between MSA and PD patients, however, in firing rates of neurons in the external globus pallidus (GPe) or in the external segment of GPi (GPie). In addition, no significant differences in firing pattern were found between MSA and PD patients. In conclusion, this study has shown that firing rates of neurons in GPii but not in GPie and GPe are different in MSA patients compared with that in PD patients, a finding that may reflect the poor clinical results of pallidotomy reported in patients with MSA. © 2004 Movement Disorder Society</div>
</front>
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<tree><country name="Canada"><region name="Ontario"><name sortKey="Pereira, Luiz C M" sort="Pereira, Luiz C M" uniqKey="Pereira L" first="Luiz C. M." last="Pereira">Luiz C. M. Pereira</name>
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<name sortKey="Dostrovsky, Jonathan O" sort="Dostrovsky, Jonathan O" uniqKey="Dostrovsky J" first="Jonathan O." last="Dostrovsky">Jonathan O. Dostrovsky</name>
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<name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D." last="Hutchison">William D. Hutchison</name>
<name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D." last="Hutchison">William D. Hutchison</name>
<name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D." last="Hutchison">William D. Hutchison</name>
<name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name>
<name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name>
<name sortKey="Palter, Vanessa N" sort="Palter, Vanessa N" uniqKey="Palter V" first="Vanessa N." last="Palter">Vanessa N. Palter</name>
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Movement Disorders (revue)

Neuronal activity in the globus pallidus of multiple system atrophy patients

Neuronal activity in the globus pallidus of multiple system atrophy patients

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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